Efficient Encapsulation of Fluorinated Drugs in the Confined Space of Water-Dispersible Fluorous Supraparticles

Pigliacelli, C.^a,b, Maiolo, D.^a, Nonappab,^c, Haataja, J.S.^b, Amenitsch, H.^d, Michelet, C.^a, Sánchez Moreno, P.^a, Tirotta, I.^a, Metrangolo, P.^a,b, Baldelli Bombelli, F.

^a Laboratory of Supramolecular and BioNano Materials (SupraBioNanoLab), Department of Chemistry, Materials, and Chemical Engineering “Giulio Natta”, Politecnico di Milano, Via L. Mancinelli 7, Milan, 20131, Italy
^b Department of Applied Physics, Aalto University School of Science, P.O. Box 11000, Aalto, 00076, Finland
^c Department of Bioproducts and Biosystems, Aalto University School of Chemical Engineering, P.O. Box 16100, Aalto, 00076, Finland
^d Elettra—Sincrotrone Trieste S.C.p.A., Strada Statale 14-km 163,5, Trieste, Basovizza 34149, Italy

Angewandte Chemie - International Edition 2017, 56(51), 16186-16190

Fluorophobic‐driven assemblies of gold nanomaterials were stabilized into water‐dispersible fluorous supraparticles by the film‐forming protein hydrophobin II. The strategy makes use of fluorous nanomaterials of different dimensions to engineer size and inner functionalization of the resulting confined space. The inner fluorous compartments allow efficient encapsulation and transport of high loadings of partially fluorinated drug molecules in water.